p53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism for Chemotherapy-Induced Cardiac Injury

The side effects of cancer therapy on normal tissues limit the success of therapy. Generation of reactive oxygen species (ROS) has been implicated for numerous chemotherapeutic agents including doxorubicin (DOX), a potent cancer chemotherapeutic drug. The production of ROS by DOX has been linked to...

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Main Authors: Velez, Joyce M., Miriyala, Sumitra, Nithipongvanitch, Ramaneeya, Noel, Teresa, Plabplueng, Chotiros D., Oberley, Terry, Jungsuwadee, Paiboon, Van Remmen, Holly, Vore, Mary, St. Clair, Daret K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068154/
https://ncbi.nlm.nih.gov/pubmed/21479164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018005
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