Thymidylate Synthase Genotype-Directed Neoadjuvant Chemoradiation for Patients With Rectal Adenocarcinoma

PURPOSE: Downstaging (DS) of rectal cancers is achieved in approximately 45% of patients with neoadjuvant fluorouracil (FU) -based chemoradiotherapy (CRT). Polymorphisms in the thymidylate synthase gene (TYMS) had previously defined two risk groups associated with disparate tumor DS rates (60% v 22%...

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Main Authors: Tan, Benjamin R., Thomas, Fabienne, Myerson, Robert J., Zehnbauer, Barbara, Trinkaus, Kathryn, Malyapa, Robert S., Mutch, Matthew G., Abbey, Elliot E., Alyasiry, Amer, Fleshman, James W., McLeod, Howard L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2011
Fag:
Original Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068061/
https://ncbi.nlm.nih.gov/pubmed/21205745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.32.3212
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