Alteration of Topoisomerase II–Alpha Gene in Human Breast Cancer: Association With Responsiveness to Anthracycline-Based Chemotherapy

PURPOSE: Approximately 35% of HER2-amplified breast cancers have coamplification of the topoisomerase II-alpha (TOP2A) gene encoding an enzyme that is a major target of anthracyclines. This study was designed to evaluate whether TOP2A gene alterations may predict incremental responsiveness to anthra...

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Autori principali: Press, Michael F., Sauter, Guido, Buyse, Marc, Bernstein, Leslie, Guzman, Roberta, Santiago, Angela, Villalobos, Ivonne E., Eiermann, Wolfgang, Pienkowski, Tadeusz, Martin, Miguel, Robert, Nicholas, Crown, John, Bee, Valerie, Taupin, Henry, Flom, Kerry J., Tabah-Fisch, Isabelle, Pauletti, Giovanni, Lindsay, Mary-Ann, Riva, Alessandro, Slamon, Dennis J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2011
Soggetti:
Original Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068060/
https://ncbi.nlm.nih.gov/pubmed/21189395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.27.5644
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