Alteration of Topoisomerase II–Alpha Gene in Human Breast Cancer: Association With Responsiveness to Anthracycline-Based Chemotherapy

PURPOSE: Approximately 35% of HER2-amplified breast cancers have coamplification of the topoisomerase II-alpha (TOP2A) gene encoding an enzyme that is a major target of anthracyclines. This study was designed to evaluate whether TOP2A gene alterations may predict incremental responsiveness to anthra...

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Xehetasun bibliografikoak
Egile Nagusiak: Press, Michael F., Sauter, Guido, Buyse, Marc, Bernstein, Leslie, Guzman, Roberta, Santiago, Angela, Villalobos, Ivonne E., Eiermann, Wolfgang, Pienkowski, Tadeusz, Martin, Miguel, Robert, Nicholas, Crown, John, Bee, Valerie, Taupin, Henry, Flom, Kerry J., Tabah-Fisch, Isabelle, Pauletti, Giovanni, Lindsay, Mary-Ann, Riva, Alessandro, Slamon, Dennis J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Clinical Oncology 2011
Gaiak:
Original Reports
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068060/
https://ncbi.nlm.nih.gov/pubmed/21189395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.27.5644
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