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Cytomegalovirus Capsid Protease: Biological Substrates Are Cleaved More Efficiently by Full-Length Enzyme (pUL80a) than by the Catalytic Domain (Assemblin)

We compared the full-length capsid maturational protease (pPR, pUL80a) of human cytomegalovirus with its proteolytic domain (assemblin) for the ability to cleave two biological substrates, and we found that pPR is more efficient with both. Affinity-purified, refolded enzymes and substrates were comb...

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Autors principals: Fernandes, Steve M., Brignole, Edward J., Gibson, Wade
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067851/
https://ncbi.nlm.nih.gov/pubmed/21270147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02663-10
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