Cleavage of Human Cytomegalovirus Protease pUL80a at Internal and Cryptic Sites Is Not Essential but Enhances Infectivity

The cytomegalovirus (CMV) maturational protease, assemblin, contains an “internal” (I) cleavage site absent from its homologs in other herpesviruses. Blocking this site for cleavage did not prevent replication of the resulting I(−) mutant virus. However, cells infected with the I(−) virus showed inc...

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Detalhes bibliográficos
Main Authors: Loveland, Amy N., Chan, Chee-Kai, Brignole, Edward J., Gibson, Wade
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1235863/
https://ncbi.nlm.nih.gov/pubmed/16188998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.20.12961-12968.2005
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