Establishment of a Chimeric, Replication-Deficient Influenza A Virus Vector by Modulation of Splicing Efficiency

Segment 8 of the influenza A virus codes for two proteins (NS1 and NS2/NEP) via splicing. Here, we developed a viral vector expressing a cytokine or chemokine instead of the interferon antagonist NS1. To achieve both the desired genetic stability and high transgene expression levels, NS2/NEP mRNA sp...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Wolschek, Markus, Samm, Elisabeth, Seper, Helena, Sturlan, Sanda, Kuznetsova, Irina, Schwager, Cornelia, Khassidov, Alexandra, Kittel, Christian, Muster, Thomas, Egorov, Andrej, Bergmann, Michael
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology (ASM) 2011
विषय:
Gene Delivery
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067781/
https://ncbi.nlm.nih.gov/pubmed/21177819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01650-10
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