Destabilization of YopE by the Ubiquitin-Proteasome Pathway Fine-Tunes Yop Delivery into Host Cells and Facilitates Systemic Spread of Yersinia enterocolitica in Host Lymphoid Tissue

Pathogenic Yersinia species inject a panel of Yop virulence proteins by type III protein secretion into host cells to modulate cellular defense responses. This enables the survival and dissemination of the bacteria in the host lymphoid tissue. We have previously shown that YopE of the Y. enterocolit...

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Main Authors: Gaus, Kristin, Hentschke, Moritz, Czymmeck, Nicole, Novikova, Lena, Trülzsch, Konrad, Valentin-Weigand, Peter, Aepfelbacher, Martin, Ruckdeschel, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067501/
https://ncbi.nlm.nih.gov/pubmed/21149597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00694-10
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