Association of Thymidylate Synthase Gene Polymorphisms with Stavudine Triphosphate Intracellular Levels and Lipodystrophy

The antiviral activity and toxicity of stavudine (d4T) depend on its triphosphate metabolite, stavudine triphosphate (d4T-TP). Therefore, modifications in intracellular levels of d4T-TP may change the toxicity profile of stavudine. d4T-TP intracellular levels in peripheral blood mononuclear cells we...

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Autori principali: Domingo, Pere, Cabeza, M. Carmen, Pruvost, Alain, Torres, Ferran, Salazar, Juliana, del Mar Gutierrez, M., Mateo, M. Gracia, Fontanet, Angels, Fernandez, Irene, Domingo, Joan C., Villarroya, Francesc, Vidal, Francesc, Baiget, Montserrat
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2011
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067160/
https://ncbi.nlm.nih.gov/pubmed/21282454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01589-10
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