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Predicting In Vitro Antibacterial Efficacy across Experimental Designs with a Semimechanistic Pharmacokinetic-Pharmacodynamic Model

We have previously described a general semimechanistic pharmacokinetic-pharmacodynamic (PKPD) model that successfully characterized the time course of antibacterial effects seen in bacterial cultures when exposed to static concentrations of five antibacterial agents of different classes. In this PKP...

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Autori principali: Nielsen, Elisabet I., Cars, Otto, Friberg, Lena E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067154/
https://ncbi.nlm.nih.gov/pubmed/21282424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01286-10
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