Desbutyl-Lumefantrine Is a Metabolite of Lumefantrine with Potent In Vitro Antimalarial Activity That May Influence Artemether-Lumefantrine Treatment Outcome

Desbutyl-lumefantrine (DBL) is a metabolite of lumefantrine. Preliminary data from Plasmodium falciparum field isolates show greater antimalarial potency than, and synergy with, the parent compound and synergy with artemisinin. In the present study, the in vitro activity and interactions of DBL were...

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Main Authors: Wong, Rina P. M., Salman, Sam, Ilett, Kenneth F., Siba, Peter M., Mueller, Ivo, Davis, Timothy M. E.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2011
主題:
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067122/
https://ncbi.nlm.nih.gov/pubmed/21199927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01312-10
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