Desbutyl-Lumefantrine Is a Metabolite of Lumefantrine with Potent In Vitro Antimalarial Activity That May Influence Artemether-Lumefantrine Treatment Outcome

Desbutyl-lumefantrine (DBL) is a metabolite of lumefantrine. Preliminary data from Plasmodium falciparum field isolates show greater antimalarial potency than, and synergy with, the parent compound and synergy with artemisinin. In the present study, the in vitro activity and interactions of DBL were...

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Detalhes bibliográficos
Main Authors: Wong, Rina P. M., Salman, Sam, Ilett, Kenneth F., Siba, Peter M., Mueller, Ivo, Davis, Timothy M. E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067122/
https://ncbi.nlm.nih.gov/pubmed/21199927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01312-10
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