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Nonoptimal DNA Topoisomerases Allow Maintenance of Supercoiling Levels and Improve Fitness of Streptococcus pneumoniae

Fluoroquinolones, which target gyrase and topoisomerase IV, are used for treating Streptococcus pneumoniae infections. Fluoroquinolone resistance in this bacterium can arise via point mutation or interspecific recombination with genetically related streptococci. Our previous study on the fitness cos...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Balsalobre, Luz, Ferrándiz, María José, de Alba, Gabriela, de la Campa, Adela G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067103/
https://ncbi.nlm.nih.gov/pubmed/21173181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00783-10
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