Human β-Defensin 2 and β-Defensin 3 Chimeric Peptides Reveal the Structural Basis of the Pathogen Specificity of Their Parent Molecules

Despite partial sequence identity and structural similarity, human β-defensin 3 (HBD3) kills Staphylococcus aureus with a 4- to 8-fold higher efficiency than human β-defensin 2 (HBD2), whereas the activities against Escherichia coli are identical. The design and characterization of HBD2/HBD3 chimeri...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Jung, Sascha, Mysliwy, Justyna, Spudy, Björn, Lorenzen, Inken, Reiss, Karina, Gelhaus, Christoph, Podschun, Rainer, Leippe, Matthias, Grötzinger, Joachim
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067091/
https://ncbi.nlm.nih.gov/pubmed/21189349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00872-10
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky