Human β-Defensin 2 and β-Defensin 3 Chimeric Peptides Reveal the Structural Basis of the Pathogen Specificity of Their Parent Molecules

Despite partial sequence identity and structural similarity, human β-defensin 3 (HBD3) kills Staphylococcus aureus with a 4- to 8-fold higher efficiency than human β-defensin 2 (HBD2), whereas the activities against Escherichia coli are identical. The design and characterization of HBD2/HBD3 chimeri...

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Bibliographic Details
Main Authors: Jung, Sascha, Mysliwy, Justyna, Spudy, Björn, Lorenzen, Inken, Reiss, Karina, Gelhaus, Christoph, Podschun, Rainer, Leippe, Matthias, Grötzinger, Joachim
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2011
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067091/
https://ncbi.nlm.nih.gov/pubmed/21189349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00872-10
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