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Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

Induction of phase 2 enzymes and elevations of glutathione are major and sufficient strategies for protecting mammals and their cells against the toxic and carcinogenic effects of electrophiles and reactive forms of oxygen. Inducers belong to nine chemical classes and have few common properties exce...

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Hlavní autoři: Dinkova-Kostova, Albena T., Massiah, Michael A., Bozak, Richard E., Hicks, Ronald J., Talalay, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC30666/
https://ncbi.nlm.nih.gov/pubmed/11248091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051632198
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