Base sequence determinants of amonafide stimulation of topoisomerase II DNA cleavage.

A number of antitumor drugs including naphthalimides, a new class of intercalating agents, interfere with the DNA breakage-reunion activity of mammalian DNA topoisomerase II resulting in DNA cleavage stimulation. In this work, the sequence specificity of a lead compound of this series, amonafide, in...

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Bibliographic Details

Published in:	Nucleic Acids Res
Main Authors:	De Isabella, P, Zunino, F, Capranico, G
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 1995
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306658/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7862525/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.2.223
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