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Single Cell Ras-GTP Analysis Reveals Altered Ras Activity in a Subpopulation of Neurofibroma Schwann Cells but Not Fibroblasts

Neurofibromatosis type 1 (NF1) is a common genetic disorder characterized by multiple neurofibromas, peripheral nerve tumors containing mainly Schwann cells and fibroblasts. The NF1 gene encodes neurofibromin, a tumor suppressor postulated to function in part as a Ras GTPase-activating protein. The...

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Autors principals: Sherman, Larry S., Atit, Radhika, Rosenbaum, Thorsten, Cox, Adrienne D., Ratner, Nancy
Format: Artigo
Idioma:Inglês
Publicat: 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066458/
https://ncbi.nlm.nih.gov/pubmed/10900196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M001702200
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