Impaired cell cycle regulation of osteoblast-related transcription factor Runx2/Cbfa1 in osteosarcoma cells

In mammals, bone differentiation requires the functional expression of the Runx2/Cbfβ heterodimeric complex. Our previous results indicate that Runx2 is also a suppressor of pre-osteoblast proliferation by affecting cell cycle progression at G(1). Runx2 levels are cell cycle regulated, oscillating f...

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Hauptverfasser: San Martin, Inga, Varela, Nelson, Gaete, Marcia, Villegas, Karina, Osorio, Mariana, Tapia, Julio C., Antonelli, Marcelo, Mancilla, Edna, Lian, Jane B., Stein, Janet L., Stein, Gary S, van Wijnen, Andre J., Galindo, Mario
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066433/
https://ncbi.nlm.nih.gov/pubmed/19739101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21894
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