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Antisense 2'-O-alkyl oligoribonucleotides are efficient inhibitors of reverse transcription.

Reverse transcription is one step of the retroviral development which can be inhibited by antisense oligonucleotides complementary to the RNA template. 2'-O-Alkyl oligoribonucleotides are of interest due to their nuclease resistance, and to the high stability of the hybrids they form with RNA. Oligo...

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Udgivet i:Nucleic Acids Res
Principais autores: Boiziau, C, Larrouy, B, Sproat, B S, Toulmé, J J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306631/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7532858/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.1.64
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