The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding

BACKGROUND & AIMS: Tumor necrosis factor (TNF) increases intestinal epithelial cell shedding and apoptosis, potentially challenging the barrier between the gastrointestinal lumen and internal tissues. We investigated the mechanism of tight junction remodeling and barrier maintenance, as well as...

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Main Authors: Marchiando, Amanda M., Shen, Le, Graham, W. Vallen, Edelblum, Karen L., Duckworth, Carrie A., Guan, Yanfang, Montrose, Marshall H., Turner, Jerrold R., Watson, Alastair J.M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066304/
https://ncbi.nlm.nih.gov/pubmed/21237166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.01.004
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