Silibinin Prevents Lung Tumorigenesis in Wild-type but not in iNOS(−/−) Mice: Potential of Real-time Micro-CT in Lung Cancer Chemoprevention Studies

PURPOSE: Sustained nitric oxide (NO) generation positively correlates with lung cancer development and progression. Herein, we genetically confirmed this role of iNOS and evaluated the chemopreventive efficacy of silibinin in carcinogen-treated B6/129 wild-type (WT) and iNOS(−/−) mice. EXPERIMENTAL...

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Auteurs principaux: Ramasamy, Kumaraguruparan, Dwyer-Nield, Lori D., Serkova, Natalie J., Hasebroock, Kendra M., Tyagi, Alpna, Raina, Komal, Singh, Rana P., Malkinson, Alvin M., Agarwal, Rajesh
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066181/
https://ncbi.nlm.nih.gov/pubmed/21148748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2290
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