Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

Class I(A) phosphatidylinositol 3-kinase (PI 3-kinase) is a key component of important intracellular signalling cascades. We have identified an adaptor protein, Ruk(l), which forms complexes with the PI 3-kinase holoenzyme in vitro and in vivo. This interaction involves the proline-rich region of Ru...

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Main Authors: Gout, Ivan, Middleton, Gayle, Adu, Jimi, Ninkina, Natalia N., Drobot, Ludmila B., Filonenko, Valery, Matsuka, Gennady, Davies, Alun M., Waterfield, Michael, Buchman, Vladimir L.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2000
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC306608/
https://ncbi.nlm.nih.gov/pubmed/10921882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.15.4015
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