TIA-1 is a translational silencer that selectively regulates the expression of TNF-α

TIA-1 and TIAR are related proteins that bind to an AU-rich element (ARE) in the 3′ untranslated region of tumor necrosis factor alpha (TNF-α) transcripts. To determine the functional significance of this interaction, we used homologous recombination to produce mutant mice lacking TIA-1. Although li...

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Autori principali: Piecyk, Monica, Wax, Stephen, Beck, Andreas R.P., Kedersha, Nancy, Gupta, Mita, Maritim, Beatrice, Chen, Samantha, Gueydan, Cyril, Kruys, Veronique, Streuli, Michel, Anderson, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2000
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC306595/
https://ncbi.nlm.nih.gov/pubmed/10921895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.15.4154
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