Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations

Inherited loss of P/Q-type calcium channel function causes human absence epilepsy, episodic dyskinesia, and ataxia, but the molecular “birthdate” of the neurological syndrome and its dependence on prenatal pathophysiology is unknown. Since these channels mediate transmitter release at synapses throu...

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Hauptverfasser: Mark, Melanie D., Maejima, Takashi, Kuckelsberg, Denise, Yoo, Jong W., Hyde, Robert A., Shah, Viral, Gutierrez, Davina, Moreno, Rosa L., Kruse, Wolfgang, Noebels, Jeffrey L., Herlitze, Stefan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065835/
https://ncbi.nlm.nih.gov/pubmed/21411672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5342-10.2011
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