Postnatal Loss of P/Q-Type Channels Confined to Rhombic-Lip-Derived Neurons Alters Synaptic Transmission at the Parallel Fiber to Purkinje Cell Synapse and Replicates Genomic Cacna1a Mutation Phenotype of Ataxia and Seizures in Mice

Ataxia, episodic dyskinesia, and thalamocortical seizures are associated with an inherited loss of P/Q-type voltage-gated Ca(2+) channel function. P/Q-type channels are widely expressed throughout the neuraxis, obscuring identification of the critical networks underlying these complex neurological d...

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Detalhes bibliográficos
Main Authors: Maejima, Takashi, Wollenweber, Patric, Teusner, Lena U.C., Noebels, Jeffrey L., Herlitze, Stefan, Mark, Melanie D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641643/
https://ncbi.nlm.nih.gov/pubmed/23516282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5442-12.2013
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