Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis

Independent studies indicate that expression of sialylated fucosylated mucins by human carcinomas portends a poor prognosis because of enhanced metastatic spread of tumor cells, that carcinoma metastasis in mice is facilitated by formation of tumor cell complexes with blood platelets, and that metas...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Borsig, Lubor, Wong, Richard, Feramisco, James, Nadeau, David R., Varki, Nissi M., Varki, Ajit
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30657/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248082/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061615598
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