Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis

Independent studies indicate that expression of sialylated fucosylated mucins by human carcinomas portends a poor prognosis because of enhanced metastatic spread of tumor cells, that carcinoma metastasis in mice is facilitated by formation of tumor cell complexes with blood platelets, and that metas...

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Bibliographic Details
Main Authors: Borsig, Lubor, Wong, Richard, Feramisco, James, Nadeau, David R., Varki, Nissi M., Varki, Ajit
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC30657/
https://ncbi.nlm.nih.gov/pubmed/11248082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061615598
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