Brain P450 Epoxygenase Activity is Required for the Antinociceptive Effects of Improgan, a Non-Opioid Analgesic

The search for the mechanism of action of improgan (a non-opioid analgesic) led to the recent discovery of CC12, a compound which blocks improgan antinociception. Since CC12 is a cytochrome P450 inhibitor, and brain P450 mechanisms were recently shown to be required in opioid analgesic signaling, ph...

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Autors principals: Hough, Lindsay B., Nalwalk, Julia W., Yang, Jun, Conroy, Jennie L., VanAlstine, Melissa A., Yang, Weizhu, Gargano, Joseph, Shan, Zhixing, Zhang, Shao-Zhong, Wentland, Mark P, Phillips, James G., Knapp, Brian I., Bidlack, Jean M., Zuiderveld, Obbe P., Leurs, Rob, Ding, Xinxin
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065546/
https://ncbi.nlm.nih.gov/pubmed/21316152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2011.01.001
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