Gp96(SIV)Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa

The ER-resident chaperone gp96, when released by cell lysis, induces an immunogenic chemokine signature and causes innate immune activation of DC and NK cells. Here we show that intraperitoneal immunization with a genetically engineered, secreted form of gp96, gp96-Ig chaperoning SIV antigens, induc...

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Detalhes bibliográficos
Main Authors: Strbo, Natasa, Vaccari, Monica, Pahwa, Savita, Kolber, Michael A., Fisher, Eva, Gonzalez, Louis, Doster, Melvin N, Hryniewicz, Anna, Felber, Barbara K., Pavlakis, George N., Franchini, Genoveffa, Podack, Eckhard R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065331/
https://ncbi.nlm.nih.gov/pubmed/21277409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.01.044
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