KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients

BACKGROUND: KRAS mutation is a negative predictive factor for treatment with anti-epidermal growth factor receptor antibody in metastatic colorectal cancer (CRC). KRAS mutation analysis is usually performed on primary tumour tissue because metastatic tissue is often not available. However, controver...

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Hlavní autoři: Knijn, N, Mekenkamp, L J M, Klomp, M, Vink-Börger, M E, Tol, J, Teerenstra, S, Meijer, J W R, Tebar, M, Riemersma, S, van Krieken, J H J M, Punt, C J A, Nagtegaal, I D
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065268/
https://ncbi.nlm.nih.gov/pubmed/21364579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.26
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