Luminal Alkalinization Attenuates Proteinuria-Induced Oxidative Damage in Proximal Tubular Cells

A highly acidic environment surrounds proximal tubular cells as a result of their reabsorption of HCO(3)(−). It is unclear whether this luminal acidity affects proteinuria-induced progression of tubular cell damage. Here, we investigated the contribution of luminal acidity to superoxide (O(2)(·−)) p...

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Main Authors: Souma, Tomokazu, Abe, Michiaki, Moriguchi, Takashi, Takai, Jun, Yanagisawa-Miyazawa, Noriko, Shibata, Eisuke, Akiyama, Yasutoshi, Toyohara, Takafumi, Suzuki, Takehiro, Tanemoto, Masayuki, Abe, Takaaki, Sato, Hiroshi, Yamamoto, Masayuki, Ito, Sadayoshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2011
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065220/
https://ncbi.nlm.nih.gov/pubmed/21372211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009111130
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