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Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein

IL-18 can be considered a proinflammatory cytokine mediating disease as well as an immunostimulatory cytokine that is important for host defense against infection and cancer. The high-affinity, constitutively expressed, and circulating IL-18 binding protein (IL-18BP), which competes with cell surfac...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kim, Soo-Hyun M., Azam, Tania, Yoon, Do-Young, Reznikov, Leonid L., Novick, Daniela, Rubinstein, Menachem, Dinarello, Charles A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30649/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248074/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051634098
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