Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein

IL-18 can be considered a proinflammatory cytokine mediating disease as well as an immunostimulatory cytokine that is important for host defense against infection and cancer. The high-affinity, constitutively expressed, and circulating IL-18 binding protein (IL-18BP), which competes with cell surfac...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Kim, Soo-Hyun M., Azam, Tania, Yoon, Do-Young, Reznikov, Leonid L., Novick, Daniela, Rubinstein, Menachem, Dinarello, Charles A.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30649/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248074/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051634098
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