Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids

Two G-quadruplex forming sequences, 5′-TGGGAG and the 17-mer sequence T30177, which exhibit anti-HIV-1 activity on cell lines, were modified using either locked nucleic acids (LNA) or via insertions of (R)-1-O-(pyren-1-ylmethyl)glycerol (intercalating nucleic acid, INA) or (R)-1-O-[4-(1-pyrenylethyn...

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Hlavní autoři: Pedersen, Erik B., Nielsen, Jakob T., Nielsen, Claus, Filichev, Vyacheslav V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Synthetic Biology and Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064782/
https://ncbi.nlm.nih.gov/pubmed/21062811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1133
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