Co-Expression of miRNA Targeting the Expression of PERK, but Not PKR, Enhances Cellular Immunity from an HIV-1 Env DNA Vaccine

Small non-coding micro-RNAs (miRNA) are important post-transcriptional regulators of mammalian gene expression that can be used to direct the knockdown of expression from targeted genes. We examined whether DNA vaccine vectors co-expressing miRNA with HIV-1 envelope (Env) antigens could influence th...

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Autors principals: Wheatley, Adam K., Kramski, Marit, Alexander, Marina R., Toe, Jesse G., Center, Rob J., Purcell, Damian F. J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064671/
https://ncbi.nlm.nih.gov/pubmed/21464971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018225
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