Altered Gene Expression in Pulmonary Tissue of Tryptophan Hydroxylase-1 Knockout Mice: Implications for Pulmonary Arterial Hypertension

The use of fenfluramines can increase the risk of developing pulmonary arterial hypertension (PAH) in humans, but the mechanisms responsible are unresolved. A recent study reported that female mice lacking the gene for tryptophan hydroxylase-1 (Tph1(−/−) mice) were protected from PAH caused by chron...

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Detalhes bibliográficos
Main Authors: Rothman, Richard B., Cadet, Jean L., Dersch, Christina M., McCoy, Michael T., Lehrmann, Elin, Becker, Kevin G., Bader, Michael, Alenina, Natalia, Baumann, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064573/
https://ncbi.nlm.nih.gov/pubmed/21464983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017735
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