Structural basis for substrate discrimination and integrin binding by autotaxin

Autotaxin (ATX) or ecto-nucleotide pyrophosphatase/phosphodiesterase-2 (ENPP2) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), a mitogen and chemo-attractant for many cell types. ATX-LPA signaling has roles in various pathologies including tumour prog...

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Main Authors: Hausmann, Jens, Kamtekar, Satwik, Christodoulou, Evangelos, Day, Jacqueline E., Wu, Tao, Fulkerson, Zachary, Albers, Harald M.H.G., van Meeteren, Laurens A., Houben, Anna, van Zeijl, Leonie, Jansen, Silvia, Andries, Maria, Hall, Troii, Pegg, Lyle E., Benson, Timothy E., Kasiem, Mobien, Harlos, Karl, Vander Kooi, Craig, Smyth, Susan S., Ovaa, Huib, Bollen, Mathieu, Morris, Andrew J., Moolenaar, Wouter H., Perrakis, Anastassis
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064516/
https://ncbi.nlm.nih.gov/pubmed/21240271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1980
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