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Effect of structural modification in the amine portion of substituted aminobutyl-benzamides as ligands for binding σ(1) and σ(2) receptors
5-Bromo-N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-butyl)]-2,3-dimethoxybenzamide (1) is one of the most potent and selective σ(2) receptor ligands reported to date. A series of new analogs, where the amine ring fused to the aromatic ring was varied in size (5 - 7) and the location of the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064429/ https://ncbi.nlm.nih.gov/pubmed/21376604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.02.006 |
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