Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes

Arginase 1, via competing with nitric oxide (NO) synthase for the substrate l-arginine, may interfere with NO-mediated vascular responses. We tested the hypothesis that arginase 1 contributes to coronary vasomotor dysfunction in patients with diabetes mellitus (DM). Coronary arterioles were dissecte...

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Bibliographic Details
Main Authors: Beleznai, Timea, Feher, Attila, Spielvogel, David, Lansman, Steven L., Bagi, Zsolt
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
Subjects:
Vascular Biology and Microcirculation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064303/
https://ncbi.nlm.nih.gov/pubmed/21217072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00831.2010
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