A Twin-track Approach Has Optimized Proton and Hydride Transfer by Dynamically Coupled Tunneling during the Evolution of Protochlorophyllide Oxidoreductase

Protein dynamics are crucial for realizing the catalytic power of enzymes, but how enzymes have evolved to achieve catalysis is unknown. The light-activated enzyme protochlorophyllide oxidoreductase (POR) catalyzes sequential hydride and proton transfers in the photoexcited and ground states, respec...

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Auteurs principaux: Heyes, Derren J., Levy, Colin, Sakuma, Michiyo, Robertson, David L., Scrutton, Nigel S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Enzymology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064235/
https://ncbi.nlm.nih.gov/pubmed/21317291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.219626
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