Parkin Ubiquitinates Drp1 for Proteasome-dependent Degradation: IMPLICATION OF DYSREGULATED MITOCHONDRIAL DYNAMICS IN PARKINSON DISEASE

Mutations in Parkin, an E3 ubiquitin ligase that regulates protein turnover, represent one of the major causes of familial Parkinson disease, a neurodegenerative disorder characterized by the loss of dopaminergic neurons and impaired mitochondrial functions. The underlying mechanism by which pathoge...

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Main Authors: Wang, Hongxia, Song, Pingping, Du, Lei, Tian, Weili, Yue, Wen, Liu, Min, Li, Dengwen, Wang, Bin, Zhu, Yushan, Cao, Cheng, Zhou, Jun, Chen, Quan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064217/
https://ncbi.nlm.nih.gov/pubmed/21292769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144238
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