β-Agonist-associated Reduction in RGS5 Expression Promotes Airway Smooth Muscle Hyper-responsiveness

Although short-acting and long-acting inhaled β(2)-adrenergic receptor agonists (SABA and LABA, respectively) relieve asthma symptoms, use of either agent alone without concomitant anti-inflammatory drugs (corticosteroids) may increase the risk of disease exacerbation in some patients. We found prev...

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Autors principals: Yang, Zhao, Cooper, Philip R., Damera, Gautam, Mukhopadhyay, Indranil, Cho, Hyeseon, Kehrl, John H., Panettieri, Reynold A., Druey, Kirk M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064200/
https://ncbi.nlm.nih.gov/pubmed/21278382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.212480
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