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N-terminal Glutamate to Pyroglutamate Conversion in Vivo for Human IgG2 Antibodies
Therapeutic proteins contain a large number of post-translational modifications, some of which could potentially impact their safety or efficacy. In one of these changes, pyroglutamate can form on the N terminus of the polypeptide chain. Both glutamine and glutamate at the N termini of recombinant m...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064176/ https://ncbi.nlm.nih.gov/pubmed/21282104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.185041 |
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