Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response

Diabetic cardiac dysfunction is associated with decreased rates of myocardial glucose oxidation (GO) and increased fatty acid oxidation (FAO), a fuel shift that has been shown to sensitize the heart to ischemic insult and ventricular dysfunction. We sought to evaluate the metabolic and functional co...

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Detalhes bibliográficos
Main Authors: Chambers, Kari T., Leone, Teresa C., Sambandam, Nandakumar, Kovacs, Attila, Wagg, Cory S., Lopaschuk, Gary D., Finck, Brian N., Kelly, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064169/
https://ncbi.nlm.nih.gov/pubmed/21321124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217349
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