In Vitro Recovery of ATP-Sensitive Potassium Channels in β-Cells From Patients With Congenital Hyperinsulinism of Infancy

OBJECTIVE: Congenital hyperinsulinism in infancy (CHI) is characterized by unregulated insulin secretion from pancreatic β-cells; severe forms are associated with defects in ABCC8 and KCNJ11 genes encoding sulfonylurea receptor 1 (SUR1) and Kir6.2 subunits, which form ATP-sensitive K(+) (K(ATP)) cha...

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Autors principals: Powell, Philippa D., Bellanné-Chantelot, Christine, Flanagan, Sarah E., Ellard, Sian, Rooman, Raoul, Hussain, Khalid, Skae, Mars, Clayton, Peter, de Lonlay, Pascale, Dunne, Mark J., Cosgrove, Karen E.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2011
Matèries:
Islet Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064095/
https://ncbi.nlm.nih.gov/pubmed/21411514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1443
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