Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality

OBJECTIVE: Thyroid hormone accelerates energy expenditure; thus, hypothyroidism is intuitively associated with obesity. However, studies failed to establish such a connection. In brown adipose tissue (BAT), thyroid hormone activation via type 2 deiodinase (D2) is necessary for adaptive thermogenesis...

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Главные авторы: Castillo, Melany, Hall, Jessica A., Correa-Medina, Mayrin, Ueta, Cintia, Won Kang, Hye, Cohen, David E., Bianco, Antonio C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2011
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064082/
https://ncbi.nlm.nih.gov/pubmed/21335378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0758
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