Macrophage Adipose Triglyceride Lipase Deficiency Attenuates Atherosclerotic Lesion Development in Low-Density Lipoprotein Receptor Knockout Mice

OBJECTIVE: The consequences of macrophage triglyceride (TG) accumulation on atherosclerosis have not been studied in detail so far. Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme for the initial step in TG hydrolysis. Because ATGL knockout (KO) mice exhibit massive TG accumulation in...

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Huvudupphovsmän: Lammers, Bart, Chandak, Prakash G., Aflaki, Elma, Van Puijvelde, Gijs H.M., Radovic, Branislav, Hildebrand, Reeni B., Meurs, Illiana, Out, Ruud, Kuiper, Johan, Van Berkel, Theo J.C., Kolb, Dagmar, Haemmerle, Guenter, Zechner, Rudolf, Levak-Frank, Sanja, Van Eck, Miranda, Kratky, Dagmar
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063945/
https://ncbi.nlm.nih.gov/pubmed/21030715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.215814
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