Alpha-synuclein aggregation induced by brief ischemia negatively impacts neuronal survival in vivo: a study in [A30P]alpha-synuclein transgenic mouse

Alpha-synuclein oligomerization and aggregation are considered to have a role in the pathogenesis of neurodegenerative diseases. However, despite numerous in vitro studies, the impact of aggregates in the intact brain is unclear. In vitro, oxidative/nitrative stress and acidity induce α-synuclein ol...

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Detalhes bibliográficos
Main Authors: Unal-Cevik, Isin, Gursoy-Ozdemir, Yasemin, Yemisci, Muge, Lule, Sevda, Gurer, Gunfer, Can, Alp, Müller, Veronica, Kahle, Philip J, Dalkara, Turgay
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063624/
https://ncbi.nlm.nih.gov/pubmed/20877387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.170
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