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The Functions of Auxilin and Rab11 in Drosophila Suggest That the Fundamental Role of Ligand Endocytosis in Notch Signaling Cells Is Not Recycling

Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling. Epsin promotes clathrin-coated vesicle formation, and auxilin uncoats clathrin from newly internalized vesicles. Two hypothe...

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Bibliografiske detaljer
Main Authors: Banks, Susan M. L., Cho, Bomsoo, Eun, Suk Ho, Lee, Ji-Hoon, Windler, Sarah L., Xie, Xuanhua, Bilder, David, Fischer, Janice A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063240/
https://ncbi.nlm.nih.gov/pubmed/21448287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018259
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