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A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation

A novel highly enantioselective two step access to a unit B precursor of cryptophycins in good yields from commercially available starting materials has been developed. The key step is an asymmetric hydrogenation using the commercially available [(COD)Rh-(R,R)-Et-DuPhos]BF(4) catalyst. The synthetic...

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Bibliografski detalji
Glavni autori: Sammet, Benedikt, Brax, Mathilde, Sewald, Norbert
Format: Artigo
Jezik:Inglês
Izdano: Beilstein-Institut 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063055/
https://ncbi.nlm.nih.gov/pubmed/21448253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.7.32
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